Science of Science

2013
Karim R. Lakhani, Kevin J. Boudreau, Po-Ru Loh, Lars Backstrom, Carliss Y. Baldwin, Eric Lonstein, Mike Lydon, Alan MacCormack, Ramy A. Arnaout, and Eva C. Guinan. 2013. “Prize-based Contests Can Provide Solutions to Computational Biology Problems.” Nature Biotechnology, 31, 2, Pp. 108-111. Publisher's VersionAbstract

In summary, we show that a prize-based contest on a commercial platform can effectively recruit skilled individuals to apply their knowledge to a big-data biomedical problem. Deconstruction and transformation of problems for a heterogeneous solver community coupled with adequate data to produce and validate results can support solution diversity and minimize the risk of sub-optimal solutions that may arise from limited searches. In addition to the benefits of generating new knowledge, this strategy may be particularly useful in situations where the computational or algorithmic problem, or potentially any science problem, represents a barrier to rapid progress but where finding the solution is not itself the major thrust of the investigator’s scientific effort. The America Competes Act passed by the US Congress provides funding agencies with the authority to administer their own prize-based contests and paves the way for establishing how grant recipients might access commercial prize platforms to accelerate their own research.

Prize-based_Contests_Can_Provide_Solutions.pdf
2011
Karim R. Lakhani. 2011. InnoCentive.com (A) (TN). Harvard Business School Teaching Notes. Harvard Business School. Publisher's VersionAbstract

Teaching Note for HBS Case 608-170

InnoCentive.com, a firm connecting R&D labs of large organizations to diverse external solvers through innovation contests, has to decide if it will enable collaboration in its community. Case covers the basics of a distributed innovation system works and the advantages of having external R&D. Links how concepts of open source are applied to a non-software setting. Describes the rationale for participation by solvers in innovation contests and the benefits that accrue to firms. Raises the issue if a community can be shifted to collaboration when competition was the basis of prior interaction.

Karim R. Lakhani and Eric Lonstein. 2011. InnoCentive.com (B). Harvard Business School Case Supplement. Harvard Business School. Publisher's VersionAbstract

InnoCentive.com enables clients to tap into internal and external solver networks to address various business issues. In 2008, InnoCentive introduced "InnoCentive@Work" (lC@W), which recognized clients' reluctance to share problems and solutions with an external network. Instead, IC@W enabled clients to foster open collaboration amongst its own employees. IC@W became the fastest growing product in InnoCentive's portfolio. In 2010, InnoCentive added "team project rooms" which allowed small groups of solvers from InnoCentive's community to openly add posts and discussion threads after agreeing to the confidentiality and IP transfer requirements of the client. The case raises the questions of how the team room concept could be improved and how clients could be convinced of its benefits.

Paul R. Carlile and Karim R. Lakhani. 2011. Innovation and the Challenge of Novelty: The Novelty-Confirmation-Transformation Cycle in Software and Science. Harvard Business School Publishing. Publisher's VersionAbstract

Innovation requires sources of novelty, but the challenge is that not all sources lead to innovation, so its value needs to be determined. However, since ways of determining value stem from existing knowledge, this often creates barriers to innovation. To understand how people address the challenge of novelty, we develop a conceptual and an empirical framework to explain how this challenge is addressed in a software and scientific context. What is shown is that the process of innovation is a cycle where actors develop a novel course of action and, based on the consequences identified, confirm what knowledge is necessary to transform and develop the next course of action. The performance of the process of innovation is constrained by the capacities of the artifacts and the ability of the actors to create and use artifacts to drive this cycle. By focusing on the challenge of novelty, a problem that cuts across all contexts of innovation, our goal is to develop a more generalized account of what drives the process of innovation.

Challenge_of_Novelty.pdf
Karim R. Lakhani. 2011. Myelin Repair Foundation: Accelerating Drug Discovery Through Collaboration (TN). Harvard Business School Teaching Notes. Harvard Business School. Publisher's VersionAbstract

Teaching Note for HBS Case 610-074.

This case presents the Myelin Repair Foundation's accelerated research collaboration model for drug discovery. It highlights the challenges of building a multi-disciplinary and multi-institutional research collaboration that is attempting to create a treatment for multiple sclerosis based on a novel scientific approach. The case provides details on how norms of academic research and intellectual property had to be updated to enable collaboration. The current dilemma facing the CEO and COO of the foundation relates to setting strategic priorities for research so that a treatment for MS can be ready in the next ten years. The strategic choices need to account for the complexities of drug discovery, the uncertainty of commercial partners' interest in the therapeutic approach and the constrained donor-based fundraising environment.

Anat Bracha, Michael Menietti, and Lise Vesterlund. 2011. “Seeds to Succeed?: Sequential Giving to Public Projects.” Journal of Public Economics, 95, 5-6, Pp. 416-427. Publisher's VersionAbstract

The public phase of a capital campaign is typically launched with the announcement of a large seed donation. Andreoni (1998) argues that such a fundraising strategy may be particularly effective when funds are being raised for projects that have fixed production costs. The reason is that when there are fixed costs of production simultaneous giving may result in both positive and zero provision equilibria. Thus absent announcements donors may get stuck in an equilibrium that fails to provide a desirable public project. Andreoni (1998) demonstrates that such inferior outcomes can be eliminated when the fundraiser initially secures a sufficiently large seed donation. We investigate this model experimentally to determine whether announcements of seed money eliminate the inefficiencies that may result under fixed costs and simultaneous provision. To assess the strength of the theory we examine the effect of announcements in both the presence and absence of fixed costs. Our findings are supportive of the theory for sufficiently high fixed costs.

Seeds_to_Succeed.pdf
2010
Karim R. Lakhani and Paul R. Carlile. 2010. Myelin Repair Foundation: Accelerating Drug Discovery Through Collaboration. Harvard Business School Case. Harvard Business School. Publisher's VersionAbstract

This case presents the Myelin Repair Foundation's accelerated research collaboration model for drug discovery. It highlights the challenges of building a multi-disciplinary and multi-institutional research collaboration that is attempting to create a treatment for multiple sclerosis based on a novel scientific approach. The case provides details on how norms of academic research and intellectual property had to be updated to enable collaboration. The current dilemma facing the CEO and COO of the foundation relates to setting strategic priorities for research so that a treatment for MS can be ready in the next ten years. The strategic choices need to account for the complexities of drug discovery, the uncertainty of commercial partners' interest in the therapeutic approach and the constrained donor-based fundraising environment.

2008
Karim R. Lakhani. 2008. InnoCentive.com (A). Harvard Business School Case. Harvard Business School. Publisher's VersionAbstract

InnoCentive.com, a firm connecting R&D labs of large organizations to diverse external solvers through innovation contests, has to decide if it will enable collaboration in its community. Case covers the basics of a distributed innovation system works and the advantages of having external R&D. Links how concepts of open source are applied to a non-software setting. Describes the rationale for participation by solvers in innovation contests and the benefits that accrue to firms. Raises the issue if a community can be shifted to collaboration when competition was the basis of prior interaction.

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